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Colostral immunity transfer defect
The calf is born without antibodies. Unlike humans, it does not receive any from its mother during gestation: the cow's placenta does not let them pass. Its only source of antibodies is colostrum, the first milk, very rich in defenses. The...
What is it?
The calf is born without antibodies. Unlike humans, it does not receive any from its mother during gestation: the cow's placenta does not let them pass.
Its only source of antibodies is colostrum, the first milk, very rich in defenses. The calf that drinks enough, early enough, is protected for its first weeks. He who lacks it is defenseless.
We speak of a lack of transfer of colostral immunity when the calf has not absorbed a sufficient quantity of antibodies. It is not an illness in itself: it is the door open to all others.
Key point
A calf without antibodies doesn't look sick from anything. The problem is not seen when it occurs: it is paid for in illnesses throughout the first month.
Commonly observed signs
These signs are neither exhaustive nor specific. Only a veterinarian can establish a diagnosis.
Related signs — each one links to its page:
There are no visible signs of the defect itself: a calf without antibodies appears normal at birth. This is what makes him formidable.
The signs appear in the form of diseases which follow one another:
Early diarrhea, more severe and longer than in the other calves in the group.
Navel infection, swollen joints.
Cough and respiratory problems in the following weeks.
Recurrent fever, calf that responds poorly to treatments or relapses.
Disappointing growth, dull coat, calf which remains small compared to its peers.
On a farm, the warning sign is collective: many sick calves, frequent treatments, unexplained deaths in the first month.
When to consult without delay
This list does not replace veterinary advice. It gathers situations that justify a prompt consultation.
Causes and risk factors
Colostrum given too late: the absorption capacity of the intestine decreases from the first hours and disappears within a day.
Insufficient quantity drunk during the first meal.
Poor quality colostrum, low in antibodies: more common in heifers, cows that dry off too short, or when the cow has leaked milk before calving.
Colostrum soiled by bacteria during milking or storage: germs interfere with the absorption of antibodies.
Calf unable to suck properly: difficult calving, weak calf, cold, or mother with poorly shaped udder.
Cow which refuses its calf or calf which cannot find the udder without being noticed.
Frozen colostrum then reheated too hard, which destroys the antibodies.
Difficult or long calving: the calf is tired, sucks late and absorbs less well.
Birth at night or unsupervised, without checking the first feeding.
Heifers at first calving, whose colostrum is often less rich.
Cows dry off too short or poorly fed at the end of gestation.
Cows having leaked milk before calving: their colostrum is already diluted.
Cold room temperature, calf getting cold and not having the strength to suckle.
Lack of frozen colostrum reserves on the farm.
Insufficient hygiene during colostrum harvesting and storage.
Diagnosis and care
Diagnosis is the veterinarian's responsibility, based on clinical examination and laboratory tests. Care is decided case by case.
The veterinarian can measure, through a blood test taken in the first days of life, the quantity of antibodies actually passed into the calf's blood.
This control is the best indicator of colostrum management on a farm. Carried out on a few calves, it tells whether the practices are working, well before diseases accumulate.
The quality of the colostrum is also controlled directly, using a simple instrument that the veterinarian can provide and explain: this allows only good colostrum to be kept and the poorest to be discarded.
In the event of repeated calf deaths, this assessment must be carried out before any other approach: it often changes the overall diagnosis.
Treatment
If the defect is spotted very early, in the very first hours of life, an additional supply of good quality colostrum can still correct the situation: the veterinarian indicates the course of action to take and, if the calf does not suck, carries out or explains the use of the probe.
After the first day, the intestine no longer absorbs the antibodies: giving colostrum will no longer protect the calf's blood, even if it retains a local digestive benefit.
For a calf already deprived of antibodies, there is no simple catch-up. The veterinarian can suggest a blood supply of antibodies in certain situations: this is a veterinary procedure, never a breeding manipulation.
The management then consists of protecting this calf: very clean individual housing, dry bedding, protection against the cold, close monitoring, intervention at the slightest sign of illness.
These calves must be reported and monitored: they will become ill more often, earlier and more seriously than others.
Treatment depends on the cause and the animal's condition: it must be determined by a veterinarian. No self-medication.
Prevention
Give colostrum as soon as possible after birth, without waiting for the calf to get up on its own: this is the most important rule of calf rearing. The veterinarian specifies the appropriate volume and rhythm.
Make sure the calf has actually drunk: see the udder emptied or, if in doubt, distribute it yourself from the bucket or teat.
Check the quality of the colostrum before giving it and discard visibly diluted or bloody colostrum.
Harvest properly: udder cleaned, equipment washed, colostrum given quickly or cooled without delay.
Build up a supply of frozen colostrum from healthy, well-vaccinated cows, in individual portions, and reheat it gently — reheating too hot destroys antibodies.
Care for cows at the end of pregnancy: sufficient drying time, balanced diet, vaccinations recommended by the veterinarian.
Monitor calving, particularly at night, and intervene quickly in the event of difficult calving.
Dry and warm the calf born in cold weather: a cold calf does not suckle.
Have the real effectiveness of these practices checked regularly, by taking blood samples from a few calves.
Vaccination
Vaccination of pregnant cows against neonatal diarrhea agents enriches colostrum with targeted antibodies.
This lever only has value if the colostrum is actually drunk, early and in sufficient quantity: without this, vaccination of the mothers does not protect any calf.
This is why colostrum management comes before any vaccination decision. The veterinarian draws up the vaccination plan for the mothers once this basis is assured.
Possible complications
Neonatal diarrhea more frequent, more severe and longer lasting.
Navel infections, arthritis, septicemia.
More numerous and more serious bronchial pneumonia in the following months.
Poor response to treatments and repeated relapses.
Long-term growth retardation, delayed age at first calving in future dairy cows.
Increased mortality during the first month of life.
Increased breeding costs: medicines, working time, culled animals.
When to see a veterinarian
Your calf has not suckled in the hours following its birth: call the same day, the absorption window closes quickly.
Calving was difficult and the calf is soft, cold or lacks the sucking reflex.
The cow has no colostrum, is refusing her calf or has leaked milk before calving.
You don't know if the calf has been drinking: ask for advice rather than guessing.
Many calves become ill or die in the first month: have the transfer of immunity checked by blood test before increasing the number of treatments.
Your calves respond poorly to treatments or relapse: the cause is often upstream, at birth.
Prognosis
A calf properly equipped with antibodies enters its first weeks with solid defenses: it is the best investment in all calf breeding.
A calf that has lacked it remains fragile for several weeks, until its own immune system takes over. With close supervision and very clean housing, many get through it, but at the cost of extensive care.
At the herd level, correcting colostrum management is the action that most effectively reduces diarrhea, navel infections and respiratory problems in calves.
Frequently asked questions
Why is colostrum so important in the early hours?
Because the calf is born without any antibodies and its intestine only knows how to absorb them very shortly after birth. This capacity diminishes hour after hour and disappears within a day. After this time, the colostrum still nourishes the calf but no longer protects it.
The calf suckles its mother: is this enough?
Not always. A calf may suckle without getting enough, especially after a difficult calving or if the udder is poorly shaped. Check that the udder has been emptied; If in doubt, distribute the colostrum yourself and ask the veterinarian for advice.
Can I freeze colostrum?
Yes, it's even an excellent practice. Take it carefully from healthy cows on your farm, freeze it in individual portions and reheat it gently when using: excessive heat destroys the antibodies.
How do I know if my calves have received their antibodies?
By a simple blood test taken by the veterinarian on a few calves in their first days. This is the only objective way, and it is one of the most cost effective controls a breeder can ask for.
Is a calf that has lacked colostrum lost?
No, but he leaves with a real handicap. You must house him in a very clean and dry place, monitor him closely and call at the slightest sign. The veterinarian can, in certain situations, suggest providing antibodies through the blood.
References
WOAH — Organisation mondiale de la santé animale (ex-OIE)
FAO — Organisation des Nations unies pour l'alimentation et l'agriculture
ANSES — Agence nationale de sécurité sanitaire (France)
Content reviewed by the TunisieVet editorial team · Updated 09 August 2026
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